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The development of anti-TNF therapy is a key step forward in rheumatology as it is the first new therapy for based on investigating the molecular mechanisms of this disease. This chapter reviews how this discovery was made.

Original publication

DOI

10.1016/j.berh.2003.09.010

Type

Journal article

Journal

Best Pract Res Clin Rheumatol

Publication Date

02/2004

Volume

18

Pages

59 - 80

Keywords

Animals, Antirheumatic Agents, Arthritis, Rheumatoid, Autoantibodies, Clinical Trials as Topic, Cytokines, Disease Models, Animal, Humans, Mice, RNA, Messenger, Research Design, Sensitivity and Specificity, Synovial Membrane, Tumor Necrosis Factor-alpha