Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

IntroductionTo investigate factors influencing survival in head and neck squamous cell carcinoma of unknown primary (HNSCCUP).MethodsA retrospective observational cohort study was conducted, over 5 years from January 2015, in UK Head and Neck centres, of consecutive adults undergoing 18F-Fluorodeoxyglucose-PET-CT within 3 months of diagnosis with metastatic cervical squamous cell carcinoma. Patients treated as HNSCCUP underwent survival analysis, stratified by neck dissection and/or radiotherapy to the ipsilateral neck, and by HPV status.ResultsData were received from 57 centres for 965 patients, of whom 482 started treatment for HNSCCUP (65.7% HPV-positive, n = 282/429). Five-year overall survival (OS) for HPV-positive patients was 85.0% (95% CI 78.4-92.3) and 43.5% (95% CI 32.9-57.5) for HPV-negative. HPV-negative status was associated with worse OS, disease-free (DFS), and disease-specific (DSS) survival (all p ConclusionsHPV status is associated with variable management and outcomes in HNSCCUP. Unilateral neck disease is treated variably and associated with poorer outcomes when managed with surgery alone. The impact of diagnostic oropharyngeal surgery on primary site emergence, survival and functional outcomes is unestablished.

Original publication

DOI

10.1111/coa.14167

Type

Journal article

Journal

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

Publication Date

09/2024

Volume

49

Pages

604 - 620

Addresses

Head and Neck Unit, The Royal Marsden Hospital, London, UK.

Keywords

INTEGRATE (The UK ENT Trainee Research Network), Humans, Head and Neck Neoplasms, Neoplasms, Unknown Primary, Neck Dissection, Survival Rate, Retrospective Studies, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male, United Kingdom, Positron Emission Tomography Computed Tomography, Squamous Cell Carcinoma of Head and Neck