Regulation of pulmonary plasma cell responses during secondary infection with influenza virus.

MacLean AJ., Bonifacio JPPL., Oram SL., Mohsen MO., Bachmann MF., Arnon TI.

During secondary infection with influenza virus, plasma cells (PCs) develop within the lung, providing a local source of antibodies. However, the site and mechanisms that regulate this process are poorly defined. Here, we show that while circulating memory B cells entered the lung during rechallenge and were activated within inducible bronchus-associated lymphoid tissues (iBALTs), resident memory B (BRM) cells responded earlier, and their activation occurred in a different niche: directly near infected alveoli. This process required NK cells but was largely independent of CD4 and CD8 T cells. Innate stimuli induced by virus-like particles containing ssRNA triggered BRM cell differentiation in the absence of cognate antigen, suggesting a low threshold of activation. In contrast, expansion of PCs in iBALTs took longer to develop and was critically dependent on CD4 T cells. Our work demonstrates that spatially distinct mechanisms evolved to support pulmonary secondary PC responses, and it reveals a specialized function for BRM cells as guardians of the alveoli.

DOI

10.1084/jem.20232014

Type

Journal article

Journal

J Exp Med

Publication Date

01/07/2024

Volume

221

Keywords

Animals, Plasma Cells, Orthomyxoviridae Infections, Lung, Mice, CD4-Positive T-Lymphocytes, Mice, Inbred C57BL, Killer Cells, Natural, CD8-Positive T-Lymphocytes, Cell Differentiation, Memory B Cells, Lymphocyte Activation, Orthomyxoviridae

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