Hip Morphology-Based Osteoarthritis Risk Prediction Models: Development and External Validation Using Individual Participant Data From the World COACH Consortium.
van den Berg MA., Boel F., van Buuren MMA., Riedstra NS., Tang J., Ahedi H., Arden NK., Bierma-Zeinstra SMA., Boer CG., Cicuttini FM., Cootes TF., Felson DT., Gielis WP., Heerey J., Jones G., Kluzek S., Lane NE., Lindner C., van Meurs JBJ., Mosler A., Nelson AE., Nevitt MC., Oei EH., Runhaar J., Weinans H., Krijthe JH., Agricola R.
OBJECTIVE: This study aims to develop hip morphology-based radiographic hip osteoarthritis (RHOA) risk prediction models and investigates the added predictive value of hip morphology measurements and the generalizability to different populations. METHODS: We combined data from nine prospective cohort studies participating in the Worldwide Collaboration on OsteoArthritis prediCtion for the Hip (World COACH) consortium. RHOA grades were harmonized, and incident RHOA was defined as hips without definite RHOA at baseline that developed definite RHOA within four to eight years. Baseline hip morphology was quantified with automatically and uniformly determined lateral center edge angle and alpha angle measurements on anteroposterior radiographs. Discriminative performance of generalized linear mixed model (GLMM) definitions with and without hip morphology measurements was determined with stratified cross-validation. With leave-one-cohort-out cross-validation, the generalizability to unseen populations of hip morphology-based GLMMs and random forest (RF) models was evaluated. RESULTS: From the included 35,984 hips without definite RHOA at baseline, 4.7% developed incident RHOA within four to eight years. The GLMM with cohort-specific intercept, considering baseline demographics, RHOA grade, and hip morphology measurements, showed a mean area under the receiver operating characteristic curve (AUC) of 0.80 (±0.01) in stratified cross-validation. Using a marginal intercept decreased performance by 0.1 in AUC. Similar results were found for a GLMM without hip morphology measurements. Leave-one-cohort-out cross-validation showed comparable discrimination (AUC between 0.56-0.88) and calibration performance for hip morphology-based GLMMs and RF models. CONCLUSION: In hips free of definite RHOA, our AUCs for the incident RHOA models showed good predictive performance in similar populations. However, the added predictive value of the morphology measurements was small, and model performance was heterogeneous in leave-one-cohort-out cross-validation.