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Proteolytic modulation of tumor microenvironment signals during cancer progression

Under normal conditions, the cellular microenvironment is optimized for the proper functioning of the tissues and organs. Cells recognize and communicate with the surrounding cells and extracellular matrix to maintain homeostasis. When cancer arises, the cellular microenvironment is modified to optimize its malignant growth, evading the host immune system and finding ways to invade and metastasize to other organs. One means is a proteolytic modification of the microenvironment and the signaling molecules. It is now well accepted that cancer progression relies on not only the performance of cancer cells but also the surrounding microenvironment. This mini-review discusses the current understanding of the proteolytic modification of the microenvironment signals during cancer progression.

Role of autophagy in immune aging

Innate immunity triggers IL-32 expression by fibroblast-like synoviocytes in rheumatoid arthritis

Gene Expression Profile According To Systemic Disease Activity In Primary Sjogren's Syndrome: Results From The Assessment Of Systemic Signs and Evolution Of Primary Sjogren's Syndrome (ASSESS) Cohort

MiR-30*Family Negatively Regulates B-Cell Activating Factor (BAFF) Synthesis in Rheumatoid Synoviocytes

A New Pathogenic Role of Salivary Gland Epithelial Cells in the Costimulation of T Lymphocytes in Primary Sjogren's Syndrome: 0X40 Ligand Expression, T-Cell Induction of OX40 and Promotion of T-Cell Survival, Proliferation and Activation

Serum IL-21 Is Increased and Associated with Higher Disease Activity and Higher Serum Levels of Markers of B-Cell Activation in Primary Sjogren's Syndrome

Salivary Gland Epithelial Cells Are Capable to Directly Induce the Differentiation of IL-21-Secreting Follicular Helper CD4 T Cells in Primary Sjogren's Syndrome

MiR-20a Regulates Negatively TLR4 Signalling Pathway by Targeting ASK1 in Rheumatoid Synoviocytes

MicroRNA-15a Regulates Etk/BMX Expression and IL-6 Release In Activated Rheumatoid Synoviocytes

MiR-30*family negatively regulates BAFF synthesis in rheumatoid synoviocytes

BAFF synthesis by rheumatoid synoviocytes is positively controled by integrin alpha5beta1 stimulation and negatively regulated by TNF-alpha and TLR ligands

THU0264 In Early Rheumatoid Arthritis (Espoir Cohort), Serum CCL19 Level is Associated with Disease Activity, Autoantibody Secretion and 3-Year Radiographic Progression: Data from the Espoir Cohort

FRI0167 Anti-TNF do not modify the interferon signature in patients with rheumatoid arthritis and lupus (“rhupus”)

IN EARLY RHEUMATOID ARTHRITIS, ELEVATED SERUM LEVELS OF IFN-REGULATED CHEMOKINES ARE ASSOCIATED WITH DISEASE ACTIVITY, AUTOANTIBODY SECRETION AND RADIOGRAPHIC PROGRESSION

A1.71 Reduced dicer expression correlates with rheumatoid arthritis

Bruton's tyrosine kinase and microRNA miR-346 regulate IL-18 release by LPS-activated rheumatoid fibroblast-like synoviocytes

A new mode of TNF-[alpha] inhibition by microRNA

Multiomics Analyses to Deliver the Most Effective Treatment to Every Patient With Inflammatory Bowel Disease.

Epidemiology and care structures for children and adolescents and young adults up to the 26th year of life with inflammatory bowel diseases (IBD) in Leipzig/Saxony/Germany

Aims: Valid data on the incidence of inflammatory bowel disease (IBD) in children and adolescents in Germany have not yet been published. Unpublished data of the Pediatric IBD Registry of Saxony (primary data source) have shown a decrease in age-specific incidence rates after the 14th year of age; therefore, a second data source was collected from adult gastroenterologists in Leipzig. Methods: All patients up to 25 years of age with a newly diagnosed IBD from adult gastroenterologists in Leipzig between 2005 and 2009 were included in the second data source: a total of 150 young patients with only two patients before age of 16 and 11 patients before age of 18 years. Results: Using a second data source, the incidence of IBD in children and adolescents up to the completion of the 18th year, as determined by IBD Registry, was corrected from 6.6/100,000 (95%-CI 5.4–8.4) to an actual incidence of 11.0/100,000 (95%-CI 9.1–12.9). Age-specific incidence of IBD was also corrected, increasing continuously until the 18th year was completed. Conclusions: Nearly all patients up to 15 years (completeness 87.5%) were recorded by pediatricians to the IBD Registry. The actual incidence up to the age of 18 years for IBD in Leipzig is one of the highest worldwide. To obtain valid epidemiologic data up to the age of 18, the inclusion of adult gastroenterologists are necessary.