Effect of vitamin d therapy on synovial tissue volume and bone marrow lesions in symptomatic knee osteoarthritis
Perry TA., O'Neill TW., Parkes MJ., Felson DT., Hodgson R., Arden NK.
Vitamin D has biological effects on multiple knee joint structures and data from observational studies suggest vitamin D deficiency may be linked with pain and progression of knee OA. In the UK VIDEO study, a multicentre 3-year randomised placebo controlled trial of vitamin D therapy (800 IU/day) in patients with symptomatic knee OA, there was no evidence of an effect of vitamin D therapy on either pain or structural progression of disease as assessed using x-rays. We hypothesised, however, that there may be an effect of treatment on the occurrence of synovial tissue volume (STV) and bone marrow lesions (BMLs), as assessed by magnetic resonance imaging (MRI).