Examining the role of chromatin modifying enzymes in medulloblastoma by utilizing a chemical library
Lokumcu T., Senbabaoglu F., Oppermann U., Bagci-Onder T.
Medulloblastoma (MB) is the most common paediatric brain tumor that arises during infancy and childhood and is a major cause of cancer related-morbidity and mortality in children. Recently, medulloblastomas are described as four distinct molecular subgroups (Wnt, sonic hedgehog, Group 3 and Group 4), which have distinct transcriptional, cytogenetic, and mutational spectra. Next-generation studies have revealed that adult medulloblastomas involve remarkably more somatic SNVs and indels than paediatric counterparts, suggesting that epigenetic deregulation might have a foremost role in the initiation and progression of paediatric medulloblastomas.