ssessing the function of chromatin modifying enzymes in medulloblastoma
Lokumcu T., Senbabaoglu F., Oppermann U., Bagci-Onder T.
Medulloblastoma is the most common pediatric brain tumor that arises during infancy and childhood and is a major cause of cancer related-morbidity and mortality in children. Recently, medulloblastomas are described as four distinct molecular subgroups (Wnt, sonic hedgehog, Group 3 and Group 4), which have distinct transcriptional, cytogenetic, and mutational spectra.