Unnikrishnan Sivan

M.Sc., Ph.D.

Postdoctoral Researcher in Cancer and Vascular Biology

My research career started as a junior research fellow in 2007, and subsequently (2009) got registered as a Ph.D. scholar. I have successfully completed my Ph.D. (2014) in stem cells and regenerative medicine from SCTIMST, Trivandrum. My Ph. D. thesis is on the study of cross lineage differentiation of human mesenchymal stem cells in vitro.

My desire to study the in vivo stem cell biology led me to the Karolinska Institutet, Stockholm, Sweden. As a postdoctoral fellow at Karolinska (2014-2018), I was exploring how a cancer-initiating (stem) cell exploits the standard homeostasis mechanisms and micro-niches, for the benefit of their survival and spatial organization during carcinogenesis.

Gradually I become more interested in understanding the role of stem cell niche in tissue regeneration, carcinogenesis, and metastasis, which brought me to Kennedy Institute of Rheumatology, at the University of Oxford.

Recent publications

Coordinated hedgehog signaling induces new hair follicles in adult skin.
Journal article

Sun X. et al, (2020), Elife, 9
The Molecular Anatomy of Mouse Skin during Hair Growth and Rest.
Journal article

Joost S. et al, (2020), Cell Stem Cell, 26, 441 - 457.e7
Role of angiocrine signals in bone development, homeostasis and disease.
Journal article

Sivan U. et al, (2019), Open Biol, 9
The molecular anatomy of mouse skin during hair growth and rest
Journal article

Joost S. et al, (2019)
Synthesis and characterization of silver nanoparticle incorporated gelatin-hydroxypropyl methacrylate hydrogels for wound dressing applications
Journal article

Resmi R. et al, (2017), JOURNAL OF APPLIED POLYMER SCIENCE, 134
Matrix-directed differentiation of human adipose-derived mesenchymal stem cells to dermal-like fibroblasts that produce extracellular matrix.
Journal article

Sivan U. et al, (2016), J Tissue Eng Regen Med, 10, E546 - E558
Dynamics of Lgr6⁺ Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis.
Journal article

Füllgrabe A. et al, (2015), Stem Cell Reports, 5, 843 - 855
Constitution of fibrin-based niche for in vitro differentiation of adipose-derived mesenchymal stem cells to keratinocytes.
Journal article

Sivan U. et al, (2014), Biores Open Access, 3, 339 - 347
The antithrombotic and antimicrobial properties of PEG-protected silver nanoparticle coated surfaces.
Journal article

Ragaseema VM. et al, (2012), Biomaterials, 33, 3083 - 3092

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