Udo Oppermann

• The first international workshop on the epigenetics of osteoarthritis.

  Journal article

  Meulenbelt IM. et al, (2017), Connect Tissue Res, 58, 37 - 48

• Sclerostin expression in bone tumours and tumour-like lesions.

  Journal article

  Inagaki Y. et al, (2016), Histopathology, 69, 470 - 478

• A germline mutation of CDKN2A and a novel RPLP1-C19MC fusion detected in a rare melanotic neuroectodermal tumor of infancy: a case report.

  Journal article

  Barnes DJ. et al, (2016), BMC Cancer, 16

• Advances and challenges in understanding histone demethylase biology.

  Journal article

  Nowak RP. et al, (2016), Curr Opin Chem Biol, 33, 151 - 159

• H3K27me3 demethylases regulate in vitro chondrogenesis and chondrocyte activity in osteoarthritis.

  Journal article

  Yapp C. et al, (2016), Arthritis Res Ther, 18

• Structural analysis of human KDM5B guides histone demethylase inhibitor development.

  Journal article

  Johansson C. et al, (2016), Nat Chem Biol, 12, 539 - 545

• Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform.

  Journal article

  Wagner T. et al, (2016), Nucleic Acids Res, 44

• H3K27ME3 DEMETHYLASES REGULATE IN VITRO CHONDROGENESIS AND CHONDROCYTE ACTIVITY IN OSTEOARTHRITIS

  Conference paper

  Yapp C. et al, (2016), OSTEOARTHRITIS AND CARTILAGE, 24, S181 - S181

• Characterization of NK Cells in Endometriosis Associated Pain.

  Conference paper

  Soderstrom K. et al, (2016), REPRODUCTIVE SCIENCES, 23, 161A - 161A

• 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.

  Journal article

  Bavetsias V. et al, (2016), J Med Chem, 59, 1388 - 1409

• Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors.

  Journal article

  Korczynska M. et al, (2016), J Med Chem, 59, 1580 - 1598

• Dendritic and mast cell involvement in the inflammatory response to primary malignant bone tumours.

  Journal article

  Inagaki Y. et al, (2016), Clin Sarcoma Res, 6

• Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding.

  Journal article

  Newman JA. et al, (2016), PLoS One, 11

• The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants.

  Journal article

  Tsoumpra MK. et al, (2015), Bone, 81, 478 - 486

• Inflammation activation and resolution in human tendon disease.

  Journal article

  Dakin SG. et al, (2015), Science Translational Medicine, 7

• Inflammation activation and resolution in human tendon disease.

  Journal article

  Dakin SG. et al, (2015), Sci Transl Med, 7

• Towards an understanding of the role of DNA methylation in rheumatoid arthritis: therapeutic and diagnostic implications.

  Journal article

  Cribbs A. et al, (2015), Ther Adv Musculoskelet Dis, 7, 206 - 219

• Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1).

  Journal article

  Yang SM. et al, (2015), J Med Chem, 58, 5967 - 5978

• Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships.

  Journal article

  Bhatia C. et al, (2015), Chem Biol Interact, 234, 114 - 125

• Human prostaglandin reductase 1 (PGR1): Substrate specificity, inhibitor analysis and site-directed mutagenesis.

  Journal article

  Mesa J. et al, (2015), Chem Biol Interact, 234, 105 - 113

• Preclinical target validation using patient-derived cells.

  Journal article

  Edwards AM. et al, (2015), Nat Rev Drug Discov, 14, 149 - 150

• Dentine Matrix Protein (DMP-1): A Marker of Bone Formation and Mineralization in Soft Tissue Tumours

  Journal article

  Athanasou N. et al, (2015), LABORATORY INVESTIGATION, 95, 14A - 14A

• Dentine Matrix Protein (DMP-1): A Marker of Bone Formation and Mineralization in Soft Tissue Tumours

  Conference paper

  Athanasou N. et al, (2015), MODERN PATHOLOGY, 28, 14A - 14A

• The role of calcium and nicotinic acid adenine dinucleotide phosphate (NAADP) in human osteoclast formation and resorption.

  Journal article

  Cheng X. et al, (2015), Calcif Tissue Int, 96, 73 - 79

• Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor.

  Journal article

  Carr SM. et al, (2014), Proc Natl Acad Sci U S A, 111, 11341 - 11346

• Pleiotropic effect of somatic mutations in the E2F subunit DP-1 gene in human cancer.

  Journal article

  Munro S. et al, (2014), Oncogene, 33, 3594 - 3603

• Human UTY(KDM6C) is a male-specific Nϵ-methyl lysyl demethylase.

  Journal article

  Walport LJ. et al, (2014), J Biol Chem, 289, 18302 - 18313

• Ribosomal oxygenases are structurally conserved from prokaryotes to humans.

  Journal article

  Chowdhury R. et al, (2014), Nature, 510, 422 - 426

• CHROMATIN MODIFYING MECHANISMS IN MACROPHAGES DIFFER BETWEEN HEALTHY CONTROLS AND PATIENTS WIH RHEUMATOID ARTHRITIS

  Conference paper

  Rooke K. et al, (2014), ANNALS OF THE RHEUMATIC DISEASES, 73, 823 - 824

• EPIGENETIC MODIFYING COMPOUNDS ALTER ACTIVITY OF PRIMARY HUMAN ARTICULAR CHONDROCYTES AND MESENCHYMAL STEM CELLS UNDERGOING CHONDROGENESIS

  Journal article

  Snelling S. et al, (2014), OSTEOARTHRITIS AND CARTILAGE, 22, S141 - S141

• The roles of Jumonji-type oxygenases in human disease.

  Journal article

  Johansson C. et al, (2014), Epigenomics, 6, 89 - 120

• A structural mapping of mutations causing succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency.

  Journal article

  Shafqat N. et al, (2013), J Inherit Metab Dis, 36, 983 - 987

• An epigenetic screen identifies bromodomain-containing protein 4 (BRD4) as a critical component for osteoblast differentiation

  Conference paper

  Kramm A. et al, (2013), INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 94, A18 - A18

• Identification of chromatin modifying mechanisms in human primary macrophages in an inflammatory model

  Conference paper

  Rooke K. et al, (2013), INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 94, A17 - A17

• Epigenetic modifying compounds alter activity of primary human articular chondrocytes and mesenchymal stem cells undergoing chondrogenesis

  Conference paper

  Snelling SJB. et al, (2013), INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 94, A16 - A16

• 5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.

  Journal article

  Hopkinson RJ. et al, (2013), Chem Sci, 4, 3110 - 3117

• Crystal structures of malonyl-coenzyme A decarboxylase provide insights into its catalytic mechanism and disease-causing mutations.

  Journal article

  Froese DS. et al, (2013), Structure, 21, 1182 - 1192

• Quantitative analysis of histone demethylase probes using fluorescence polarization.

  Journal article

  Xu W. et al, (2013), J Med Chem, 56, 5198 - 5202

• Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits.

  Journal article

  Shafqat N. et al, (2013), Biochem J, 452, 27 - 36

• Dentine matrix protein 1 (DMP-1) is a marker of bone-forming tumours.

  Journal article

  Kashima TG. et al, (2013), Virchows Arch, 462, 583 - 591

• Why is epigenetics important in understanding the pathogenesis of inflammatory musculoskeletal diseases?

  Journal article

  Oppermann U., (2013), Arthritis Res Ther, 15

• EPIGENETIC MODIFYING COMPOUNDS AFFECT THE ACTIVITY OF PRIMARY HUMAN ARTICULAR CHONDROCYTES AND MESENCHYMAL STEM CELLS UNDERGOING CHONDROGENESIS

  Conference paper

  Snelling S. et al, (2013), OSTEOARTHRITIS AND CARTILAGE, 21, S131 - S131

• Structure and mechanism of human UDP-xylose synthase: evidence for a promoting role of sugar ring distortion in a three-step catalytic conversion of UDP-glucuronic acid.

  Journal article

  Eixelsberger T. et al, (2012), J Biol Chem, 287, 31349 - 31358

• A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.

  Journal article

  Kruidenier L. et al, (2012), Nature, 488, 404 - 408

• Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.

  Journal article

  Rose NR. et al, (2012), J Med Chem, 55, 6639 - 6643

• Development and application of a fluoride-detection-based fluorescence assay for γ-butyrobetaine hydroxylase.

  Journal article

  Rydzik AM. et al, (2012), Chembiochem, 13, 1559 - 1563

• Structure of MMACHC reveals an arginine-rich pocket and a domain-swapped dimer for its B12 processing function.

  Journal article

  Froese DS. et al, (2012), Biochemistry, 51, 5083 - 5090

• Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family.

  Journal article

  Chaikuad A. et al, (2012), BMC Struct Biol, 12

• Crystal structure of the secretory isozyme of mammalian carbonic anhydrases CA VI: implications for biological assembly and inhibitor development.

  Journal article

  Pilka ES. et al, (2012), Biochem Biophys Res Commun, 419, 485 - 489

• Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases.

  Journal article

  Woon EC. et al, (2012), Angew Chem Int Ed Engl, 51, 1631 - 1634

• Structural and kinetic evidence that catalytic reaction of human UDP-glucose 6-dehydrogenase involves covalent thiohemiacetal and thioester enzyme intermediates.

  Journal article

  Egger S. et al, (2012), J Biol Chem, 287, 2119 - 2129

• Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis.

  Journal article

  Chaikuad A. et al, (2011), Proc Natl Acad Sci U S A, 108, 21028 - 21033

• Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family.

  Journal article

  Hillringhaus L. et al, (2011), J Biol Chem, 286, 41616 - 41625

• Directed differentiation of human induced pluripotent stem cells into chondrocytes

  Conference paper

  Hala S. et al, (2011), INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 92, A21 - A22

• Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.

  Journal article

  Evans DM. et al, (2011), Nat Genet, 43, 761 - 767

• Structure and mechanism of human UDP-glucose 6-dehydrogenase.

  Journal article

  Egger S. et al, (2011), J Biol Chem, 286, 23877 - 23887

• The relationship between the chemistry and biological activity of the bisphosphonates.

  Journal article

  Ebetino FH. et al, (2011), Bone, 49, 20 - 33

• A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases.

  Journal article

  Luo X. et al, (2011), J Am Chem Soc, 133, 9451 - 9456

• High-throughput structural biology of metabolic enzymes and its impact on human diseases.

  Journal article

  Yue WW. and Oppermann U., (2011), J Inherit Metab Dis, 34, 575 - 581

• Structural basis of fumarate hydratase deficiency.

  Journal article

  Picaud S. et al, (2011), J Inherit Metab Dis, 34, 671 - 676

• Interactive JIMD articles using the iSee concept: turning a new page on structural biology data.

  Journal article

  Lee WH. et al, (2011), J Inherit Metab Dis, 34, 565 - 567

• Crystal structure of PHYHD1A, a 2OG oxygenase related to phytanoyl-CoA hydroxylase.

  Journal article

  Zhang Z. et al, (2011), Biochem Biophys Res Commun, 408, 553 - 558

• Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming.

  Journal article

  Kochan G. et al, (2011), Proc Natl Acad Sci U S A, 108, 7745 - 7750

• Structure and kinetic characterization of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase, GAPDS.

  Journal article

  Chaikuad A. et al, (2011), Biochem J, 435, 401 - 409

• Kinetic and structural evidence of the alkenal/one reductase specificity of human ζ-crystallin.

  Journal article

  Porté S. et al, (2011), Cell Mol Life Sci, 68, 1065 - 1077

• Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites.

  Journal article

  Artz JD. et al, (2011), J Biol Chem, 286, 3315 - 3322

• Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein.

  Journal article

  Carr SM. et al, (2011), EMBO J, 30, 317 - 327

• The crystal structure of human GLRX5: iron-sulfur cluster co-ordination, tetrameric assembly and monomer activity.

  Journal article

  Johansson C. et al, (2011), Biochem J, 433, 303 - 311

• DELINEATING THE MITOCHONDRIAL VITAMIN B12 PATHWAY THROUGH STRUCTURAL AND INTERACTION STUDIES

  Journal article

  Froese DS. et al, (2011), JOURNAL OF INHERITED METABOLIC DISEASE, 34, S119 - S119

• Animal models of epigenetic regulation in neuropsychiatric disorders.

  Journal article

  Bountra C. et al, (2011), Curr Top Behav Neurosci, 7, 281 - 322

• INTERACTIVE 3D VISUALISATIONS OF PROTEIN STRUCTURES TO AID THE STUDY OF INBORN ERRORS OF METABOLISM

  Journal article

  Lee WH. et al, (2011), JOURNAL OF INHERITED METABOLIC DISEASE, 34, S240 - S240

• Structural and mechanistic studies on γ-butyrobetaine hydroxylase.

  Journal article

  Leung IK. et al, (2010), Chem Biol, 17, 1316 - 1324

• Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation.

  Journal article

  Froese DS. et al, (2010), J Biol Chem, 285, 38204 - 38213

• Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.

  Journal article

  King ON. et al, (2010), PLoS One, 5

• High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships.

  Journal article

  Niesen FH. et al, (2010), PLoS One, 5

• Structural genomics of histone tail recognition.

  Journal article

  Wang M. et al, (2010), Bioinformatics, 26, 2629 - 2630

• UDP-glucose dehydrogenase: structure and function of a potential drug target.

  Journal article

  Egger S. et al, (2010), Biochem Soc Trans, 38, 1378 - 1385

• Development of homogeneous luminescence assays for histone demethylase catalysis and binding.

  Journal article

  Kawamura A. et al, (2010), Anal Biochem, 404, 86 - 93

• Crystal structure of the 2-oxoglutarate- and Fe(II)-dependent lysyl hydroxylase JMJD6.

  Journal article

  Mantri M. et al, (2010), J Mol Biol, 401, 211 - 222

• Quinone oxidoreductase-2-mediated prodrug cancer therapy.

  Journal article

  Middleton MR. et al, (2010), Sci Transl Med, 2

• Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress.

  Journal article

  Brocker C. et al, (2010), J Biol Chem, 285, 18452 - 18463

• Structural impact of human and Escherichia coli biotin carboxyl carrier proteins on biotin attachment.

  Journal article

  Healy S. et al, (2010), Biochemistry, 49, 4687 - 4694

• Superfamilies SDR and MDR: from early ancestry to present forms. Emergence of three lines, a Zn-metalloenzyme, and distinct variabilities.

  Journal article

  Jörnvall H. et al, (2010), Biochem Biophys Res Commun, 396, 125 - 130

• Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design.

  Journal article

  Shafqat N. et al, (2010), J Mol Biol, 398, 497 - 506

• Thermolability of mutant MMACHC protein in the vitamin B12-responsive cblC disorder.

  Journal article

  Froese DS. et al, (2010), Mol Genet Metab, 100, 29 - 36

• Classification of the short-chain dehydrogenase/reductase superfamily using hidden Markov models.

  Journal article

  Kallberg Y. et al, (2010), FEBS J, 277, 2375 - 2386

• Designed mutants of human farnesyl pyrophosphate synthase (FPPS) help to characterise the interactions of nitrogen-containing bisphosphonates with Tyrosine 204 and Phenylalanine 239 side-chain residues

  Conference paper

  Tsoumpra M. et al, (2010), BONE, 46, S23 - S23

• Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.

  Journal article

  Rose NR. et al, (2010), J Med Chem, 53, 1810 - 1818

• Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase.

  Journal article

  Yue WW. et al, (2010), FEBS Lett, 584, 825 - 830

• A miniaturized screen for inhibitors of Jumonji histone demethylases.

  Journal article

  Sakurai M. et al, (2010), Mol Biosyst, 6, 357 - 364

• A non-enzymatic function of 17beta-hydroxysteroid dehydrogenase type 10 is required for mitochondrial integrity and cell survival.

  Journal article

  Rauschenberger K. et al, (2010), EMBO Mol Med, 2, 51 - 62

• A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics.

  Journal article

  Quinn AM. et al, (2010), Nucleic Acids Res, 38

• THE GENETICS OF ERAP1 IN ANKYLOSING SPONDYLITIS

  Journal article

  Wordsworth BP. et al, (2010), CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 28, 603 - 603

• INVESTIGATING THE ROLE OF ENDOPLASMIC RETICULUM AMINOPEPTIDASE-1 (ERAP1) IN ANKYLOSING SPONDYLITIS

  Journal article

  Chen L. et al, (2010), CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 28, 631 - 631

• IMPACT OF ANKYLOSING SPONDYLITIS-ASSOCIATED ERAP1 VARIANTS ON ITS AMINOPEPTIDASE ACTIVITY

  Journal article

  Harvey D. et al, (2010), CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 28, 607 - 607

• Investigating the genetic association between ERAP1 and ankylosing spondylitis.

  Journal article

  Harvey D. et al, (2009), Hum Mol Genet, 18, 4204 - 4212

• Structural basis for substrate specificity in human monomeric carbonyl reductases.

  Journal article

  Pilka ES. et al, (2009), PLoS One, 4

• Tic32, an essential component in chloroplast biogenesis. (vol 279, pg 34756, 2004)

  Journal article

  Hoermann F. et al, (2009), JOURNAL OF BIOLOGICAL CHEMISTRY, 284, 29240 - 29240

• Crystal structure of human carbonic anhydrase-related protein VIII reveals the basis for catalytic silencing.

  Journal article

  Picaud SS. et al, (2009), Proteins, 76, 507 - 511

• Structural basis for different specificities of acyltransferases associated with the human cytosolic and mitochondrial fatty acid synthases.

  Journal article

  Bunkoczi G. et al, (2009), Chem Biol, 16, 667 - 675

• Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3.

  Journal article

  Porté S. et al, (2009), J Biol Chem, 284, 17194 - 17205

• Evidence for the involvement of the threonine 201 side-chain in the interaction of nitrogen-containing bisphosphonates with farnesyl pyrophosphate synthase

  Conference paper

  Kwassi AAA. et al, (2009), BONE, 44, S323 - S323

• Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A.

  Journal article

  Kochan G. et al, (2009), J Mol Biol, 388, 997 - 1008

• REFINING THE GENETIC ASSOCIATION BETWEEN ANKYLOSING SPODYLITIS AND ERAP1

  Conference paper

  Harvey D. et al, (2009), RHEUMATOLOGY, 48, I52 - I52

• Short-term glucocorticoid treatment increases insulin secretion in islets derived from lean mice through multiple pathways and mechanisms.

  Journal article

  Hult M. et al, (2009), Mol Cell Endocrinol, 301, 109 - 116

• Structure-activity relationships of human AKR-type oxidoreductases involved in bile acid synthesis: AKR1D1 and AKR1C4.

  Journal article

  Lee WH. et al, (2009), Mol Cell Endocrinol, 301, 199 - 204

• The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative.

  Journal article

  Persson B. et al, (2009), Chem Biol Interact, 178, 94 - 98

• Analysis of the substrate-binding site of human carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis.

  Journal article

  El-Hawari Y. et al, (2009), Chem Biol Interact, 178, 234 - 241

• The human short-chain dehydrogenase/reductase (SDR) superfamily: a bioinformatics summary.

  Journal article

  Bray JE. et al, (2009), Chem Biol Interact, 178, 99 - 109

• Dynamic protein methylation in chromatin biology.

  Journal article

  Ng SS. et al, (2009), Cell Mol Life Sci, 66, 407 - 422

• Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone.

  Journal article

  Zimmermann TJ. et al, (2009), Bioorg Med Chem, 17, 530 - 536

• A NON-ENZYMATIC FUNCTION OF 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 10 IS REQUIRED FOR MITOCHONDRIAL INTEGRITY AND CELL SURVIVAL

  Conference paper

  Zschocke J. et al, (2009), MOLECULAR GENETICS AND METABOLISM, 98, 5 - 5

• Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis.

  Journal article

  Artz JD. et al, (2008), Chem Biol, 15, 1296 - 1306

• Medium- and short-chain dehydrogenase/reductase gene and protein families : the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes.

  Journal article

  Kavanagh KL. et al, (2008), Cell Mol Life Sci, 65, 3895 - 3906

• Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.

  Journal article

  Rose NR. et al, (2008), J Med Chem, 51, 7053 - 7056

• Thermal unfolding of the archaeal DNA and RNA binding protein Ssh10.

  Journal article

  Wu X. et al, (2008), Biochem Biophys Res Commun, 373, 482 - 487

• The Role of Active Site Threonine 201 in the Inhibition of Farnesyl Pyrophosphate Synthase by Nitrogen Containing Bisphosphonates

  Conference paper

  Dunford JE. et al, (2008), JOURNAL OF BONE AND MINERAL RESEARCH, 23, S122 - S122

• CARB 4-Elucidating the mechanism of human UDP-glucose dehydrogenase using kinetic, mutational and structural studies

  Conference paper

  Egger S. et al, (2008), ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 236

• Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study.

  Journal article

  Burgess-Brown NA. et al, (2008), Protein Expr Purif, 59, 94 - 102

• Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.

  Journal article

  Dunford JE. et al, (2008), J Med Chem, 51, 2187 - 2195

• Crystal structures of the acyl transferases involved in the human cytosolic and mitochondrial fatty acid synthase

  Journal article

  Misquitta SA. et al, (2008), FASEB JOURNAL, 22

• Role of short-chain hydroxyacyl CoA dehydrogenases in SCHAD deficiency.

  Journal article

  Filling C. et al, (2008), Biochem Biophys Res Commun, 368, 6 - 11

• The interaction of sidechain nitrogen with active site threonine is not essential for inhibition of farnesyl pyrophosphate synthase by nitrogen containing bisphosphonates

  Conference paper

  Dunford JE. et al, (2008), BONE, 42, S70 - S71

• Structure activity relationships of nitrogen containing bisphosphonates which induce conformational changes in farnesyl pyrophosphate synthase

  Conference paper

  Dunford JE. et al, (2008), BONE, 42, S71 - S71

• Characterization of the human carbonyl reductase 3 (CBR3) by site-directed mutagenesis

  Conference paper

  El-Hawari Y. et al, (2008), NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 377, 67 - 67

• Protein production and purification.

  Journal article

  Structural Genomics Consortium None. et al, (2008), Nat Methods, 5, 135 - 146

• Ligand supplementation as a method to increase soluble heterologous protein production.

  Journal article

  Hozjan V. et al, (2008), Expert Rev Proteomics, 5, 137 - 143

• SALMON: solvent accessibility, ligand binding, and mapping of ligand orientation by NMR spectroscopy.

  Journal article

  Ludwig C. et al, (2008), J Med Chem, 51, 1 - 3

• Interaction of the active site threonine 201 sidechain with the nitrogen of nttrogen-containing bisphosphonates is not essential for slow tight inhibition to farnesyl pyrophosphate synthase

  Journal article

  Dunford JE. et al, (2008), CALCIFIED TISSUE INTERNATIONAL, 82, S223 - S223

• Evaluation of micro-parallel liquid chromatography as a method for HTS-coupled actives verification.

  Journal article

  Simeonov A. et al, (2007), Assay Drug Dev Technol, 5, 815 - 824

• Mechanism and substrate recognition of human holo ACP synthase.

  Journal article

  Bunkoczi G. et al, (2007), Chem Biol, 14, 1243 - 1253

• Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy.

  Journal article

  Russell RG. et al, (2007), Ann N Y Acad Sci, 1117, 209 - 257

• The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins.

  Journal article

  Gileadi O. et al, (2007), J Struct Funct Genomics, 8, 107 - 119

• Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.

  Journal article

  Ng SS. et al, (2007), Nature, 448, 87 - 91

• Nitrogen-containing bisphosphonates and prediction of their clinical potencies: Dissociation of target enzyme- and hydroxyapatite-binding affinities

  Conference paper

  Xia Z. et al, (2007), JOURNAL OF BONE AND MINERAL RESEARCH, 22, 1125 - 1125

• Predicting pharmacological potencies of nitrogen-containing bisphosphonates; novel methods dissociate enzyme- and hydroxyapatite-binding affinities

  Conference paper

  Xia Z. et al, (2007), BONE, 40, S301 - S302

• Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity.

  Journal article

  Lukacik P. et al, (2007), Biochem J, 402, 419 - 427

• Structural genomics and drug discovery: Case studies on human metabolic enzymes

  Conference paper

  Oppermann U. et al, (2007), NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 375, 69 - 69

• Biochemical characterization of TASSELSEED 2, an essential plant short-chain dehydrogenase/reductase with broad spectrum activities.

  Journal article

  Wu X. et al, (2007), FEBS J, 274, 1172 - 1182

• Reversible sequestration of active site cysteines in a 2Fe-2S-bridged dimer provides a mechanism for glutaredoxin 2 regulation in human mitochondria.

  Journal article

  Johansson C. et al, (2007), J Biol Chem, 282, 3077 - 3082

• SDR-type human hydroxysteroid dehydrogenases involved in steroid hormone activation.

  Journal article

  Wu X. et al, (2007), Mol Cell Endocrinol, 265-266, 71 - 76

• Kinetic analysis of conformational changes in farnesyl pyrophosphate synthase induced by nitrogen containing bisphosphonates

  Journal article

  Dunford JE. et al, (2007), CALCIFIED TISSUE INTERNATIONAL, 80, S41 - S42

• Carbonyl reductases: the complex relationships of mammalian carbonyl- and quinone-reducing enzymes and their role in physiology.

  Journal article

  Oppermann U., (2007), Annu Rev Pharmacol Toxicol, 47, 293 - 322

• Type 1 11beta-hydroxysteroid dehydrogenase as universal drug target in metabolic diseases?

  Journal article

  Oppermann U., (2006), Endocr Metab Immune Disord Drug Targets, 6, 259 - 269

• Analysis of the kinetic mechanism of inhibition of Farnesyl Pyrophosphate Synthase by nitrogen containing bisphosphonates.

  Conference paper

  Dunford JE. et al, (2006), JOURNAL OF BONE AND MINERAL RESEARCH, 21, S396 - S397

• The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding.

  Journal article

  Kavanagh KL. et al, (2006), J Biol Chem, 281, 22004 - 22012

• The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.

  Journal article

  Kavanagh KL. et al, (2006), Proc Natl Acad Sci U S A, 103, 7829 - 7834

• Hep27, a member of the short-chain dehydrogenase/reductase family, is an NADPH-dependent dicarbonyl reductase expressed in vascular endothelial tissue.

  Journal article

  Shafqat N. et al, (2006), Cell Mol Life Sci, 63, 1205 - 1213

• Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase.

  Journal article

  Guo K. et al, (2006), J Biol Chem, 281, 10291 - 10297

• Structure and function of human 17beta-hydroxysteroid dehydrogenases.

  Journal article

  Lukacik P. et al, (2006), Mol Cell Endocrinol, 248, 61 - 71

• Active site variability of type 1 11beta-hydroxysteroid dehydrogenase revealed by selective inhibitors and cross-species comparisons.

  Journal article

  Hult M. et al, (2006), Mol Cell Endocrinol, 248, 26 - 33

• Molecular modeling comparison of nitrogen-containing bisphosphonates of varying potency co-crystalized in farnesyl diphosphate synthase

  Conference paper

  Ebetino FH. et al, (2006), BONE, 38, S49 - S50

• Investigations into the kinetic mechanism of inhibition of farnesyl diphosphate synthase by nitrogen containing bisphosphonates

  Conference paper

  Dunford JE. et al, (2006), BONE, 38, S47 - S48

• Human farnesyl diphosphate synthase crystal structures with active and inactive bisphosphonates

  Conference paper

  Evdokimov A. et al, (2006), BONE, 38, S49 - S49

• Crystal structures and molecular interactions of risedronate and zoledronate with human farnesyl diphosphate synthase

  Conference paper

  Kavanagh KL. et al, (2006), BONE, 38, S53 - S53

• SDR goes SGC: A structural genomics initiative

  Conference paper

  Oppermann U. et al, (2006), Enzymology and Molecular Biology of Carbonyl Metabolism 12, 12, 235 - 241

• Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease.

  Journal article

  McDonough MA. et al, (2005), J Biol Chem, 280, 41101 - 41110

• Human farnesyl diphosphate synthase (FDFS): Crystal structure and molecular interactions with Nnitrogen-containing bisphosphonates.

  Conference paper

  Kavanagh K. et al, (2005), JOURNAL OF BONE AND MINERAL RESEARCH, 20, S95 - S96

• The crystal structure of guinea pig 11beta-hydroxysteroid dehydrogenase type 1 provides a model for enzyme-lipid bilayer interactions.

  Journal article

  Ogg D. et al, (2005), J Biol Chem, 280, 3789 - 3794

• Tic32, an essential component in chloroplast biogenesis.

  Journal article

  Hörmann F. et al, (2004), J Biol Chem, 279, 34756 - 34762

• High-level production and optimization of monodispersity of 11beta-hydroxysteroid dehydrogenase type 1.

  Journal article

  Elleby B. et al, (2004), Biochim Biophys Acta, 1700, 199 - 207

• Crystal structure and biophysical characterization of human GDP-D-mannose 4, 6-dehydratase

  Conference paper

  Vedadi M. et al, (2004), PROTEIN SCIENCE, 13, 81 - 82

• Membrane protein isolation by in situ solubilization, partitioning and affinity adsorption in aqueous two-phase systems. Purification of the human type 1 11beta-hydroxysteroid dehydrogenase.

  Journal article

  Roobol-Bóza M. et al, (2004), J Chromatogr A, 1043, 217 - 223

• Human and rodent type 1 11beta-hydroxysteroid dehydrogenases are 7beta-hydroxycholesterol dehydrogenases involved in oxysterol metabolism.

  Journal article

  Hult M. et al, (2004), Cell Mol Life Sci, 61, 992 - 999

• Codon optimization reveals critical factors for high level expression of two rare codon genes in Escherichia coli: RNA stability and secondary structure but not tRNA abundance.

  Journal article

  Wu X. et al, (2004), Biochem Biophys Res Commun, 313, 89 - 96

• Expanded substrate screenings of human and Drosophila type 10 17beta-hydroxysteroid dehydrogenases (HSDs) reveal multiple specificities in bile acid and steroid hormone metabolism: characterization of multifunctional 3alpha/7alpha/7beta/17beta/20beta/21-HSD.

  Journal article

  Shafqat N. et al, (2003), Biochem J, 376, 49 - 60

• Molecular mechanisms underlying WOX1 activation during apoptotic and stress responses.

  Journal article

  Chang NS. et al, (2003), Biochem Pharmacol, 66, 1347 - 1354

• Hot spots in Tcf4 for the interaction with beta-catenin.

  Journal article

  Fasolini M. et al, (2003), J Biol Chem, 278, 21092 - 21098

• High-level expression and rapid purification of rare-codon genes from hyperthermophilic archaea by the GST gene fusion system.

  Journal article

  Wu X. and Oppermann U., (2003), J Chromatogr B Analyt Technol Biomed Life Sci, 786, 177 - 185

• Glucocorticoid activation by 11beta-hydroxysteroid dehydrogenase type 1: A novel pharmacological target in the metabolic syndrome

  Conference paper

  Oppermann U. et al, (2003), NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 367, R13 - R13

• Short-chain dehydrogenases/reductases (SDR): the 2002 update.

  Journal article

  Oppermann U. et al, (2003), Chem Biol Interact, 143-144, 247 - 253

• Coenzyme-based functional assignments of short-chain dehydrogenases/reductases (SDRs).

  Journal article

  Persson B. et al, (2003), Chem Biol Interact, 143-144, 271 - 278

• Comparative enzymology of 11 beta -hydroxysteroid dehydrogenase type 1 from glucocorticoid resistant (Guinea pig) versus sensitive (human) species.

  Journal article

  Shafqat N. et al, (2003), J Biol Chem, 278, 2030 - 2035

• Structure of bacterial 3beta/17beta-hydroxysteroid dehydrogenase at 1.2 A resolution: a model for multiple steroid recognition.

  Journal article

  Benach J. et al, (2002), Biochemistry, 41, 14659 - 14668

• Short-chain dehydrogenases/reductases (SDRs).

  Journal article

  Kallberg Y. et al, (2002), Eur J Biochem, 269, 4409 - 4417

• Liver X receptors downregulate 11beta-hydroxysteroid dehydrogenase type 1 expression and activity.

  Journal article

  Stulnig TM. et al, (2002), Diabetes, 51, 2426 - 2433

• Critical residues for structure and catalysis in short-chain dehydrogenases/reductases.

  Journal article

  Filling C. et al, (2002), J Biol Chem, 277, 25677 - 25684

• Short-chain dehydrogenase/reductase (SDR) relationships: a large family with eight clusters common to human, animal, and plant genomes.

  Journal article

  Kallberg Y. et al, (2002), Protein Sci, 11, 636 - 641

• Structural role of conserved Asn179 in the short-chain dehydrogenase/reductase scaffold.

  Journal article

  Filling C. et al, (2001), Biochem Biophys Res Commun, 289, 712 - 717

• Metabolic conversion as a pre-receptor control mechanism for lipophilic hormones.

  Journal article

  Nobel S. et al, (2001), Eur J Biochem, 268, 4113 - 4125

• Novel enzymological profiles of human 11beta-hydroxysteroid dehydrogenase type 1.

  Journal article

  Hult M. et al, (2001), Chem Biol Interact, 130-132, 805 - 814

• Forms and functions of human SDR enzymes.

  Journal article

  Oppermann UC. et al, (2001), Chem Biol Interact, 130-132, 699 - 705

• Subcellular targeting analysis of SDR-type hydroxysteroid dehydrogenases.

  Journal article

  Filling C. et al, (2001), Mol Cell Endocrinol, 171, 99 - 101

• Human type 10 17 beta-hydroxysteroid dehydrogenase: molecular modelling and substrate docking.

  Journal article

  Nordling E. et al, (2001), J Mol Graph Model, 19, 514 - 593

• Type 1 11beta -hydroxysteroid dehydrogenase mediates glucocorticoid activation and insulin release in pancreatic islets.

  Journal article

  Davani B. et al, (2000), J Biol Chem, 275, 34841 - 34844

• Molecular and structural aspects of xenobiotic carbonyl metabolizing enzymes. Role of reductases and dehydrogenases in xenobiotic phase I reactions.

  Journal article

  Oppermann UC. and Maser E., (2000), Toxicology, 144, 71 - 81

• Lack of quinone reductase activity suggests that amyloid-beta peptide/ERAB induced lipid peroxidation is not directly related to production of reactive oxygen species by redoxcycling.

  Journal article

  Salim S. et al, (2000), Toxicology, 144, 163 - 168

• Heterogeneity of 11beta-hydroxysteroid dehydrogenase type 1/microsomal carbonyl reductase (11beta-HSD/CR) in guinea pig tissues. Purification of the liver form suggests modification in the cosubstrate binding site.

  Journal article

  Oppermann UC. et al, (2000), Toxicology, 144, 63 - 69

• Human liver class I alcohol dehydrogenase gammagamma isozyme: the sole cytosolic 3beta-hydroxysteroid dehydrogenase of iso bile acids.

  Journal article

  Marschall HU. et al, (2000), Hepatology, 31, 990 - 996

• Characterization of gel separated proteins

  Conference paper

  Bergman AC. et al, (2000), PROTEOME AND PROTEIN ANALYSIS, 81 - 87

• An ethanol-inducible MDR ethanol dehydrogenase/acetaldehyde reductase in Escherichia coli: structural and enzymatic relationships to the eukaryotic protein forms.

  Journal article

  Shafqat J. et al, (1999), Eur J Biochem, 263, 305 - 311

• Binding of amyloid beta-peptide to mitochondrial hydroxyacyl-CoA dehydrogenase (ERAB): regulation of an SDR enzyme activity with implications for apoptosis in Alzheimer's disease.

  Journal article

  Oppermann UC. et al, (1999), FEBS Lett, 451, 238 - 242

• Studies on variants of alcohol dehydrogenases and its domains.

  Journal article

  Shafqat J. et al, (1999), Adv Exp Med Biol, 463, 285 - 293

• Structure-function relationships of 3 beta-hydroxysteroid dehydrogenases involved in bile acid metabolism.

  Journal article

  Filling C. et al, (1999), Adv Exp Med Biol, 463, 389 - 394

• Regulatory factors and motifs in SDR enzymes.

  Journal article

  Oppermann U. et al, (1999), Adv Exp Med Biol, 463, 365 - 371

• Bioinformatics in studies of SDR and MDR enzymes.

  Journal article

  Persson B. et al, (1999), Adv Exp Med Biol, 463, 373 - 377

• Selective inhibition of human type 1 11beta-hydroxysteroid dehydrogenase by synthetic steroids and xenobiotics.

  Journal article

  Hult M. et al, (1998), FEBS Lett, 441, 25 - 28

• Isolation and structure of repressor-like proteins from the archaeon Sulfolobus solfataricus. Co-purification of RNase A with Sso7c.

  Journal article

  Oppermann UC. et al, (1998), FEBS Lett, 432, 141 - 144

• Carbonyl reduction of an anti-insect agent imidazole analogue of metyrapone in soil bacteria, invertebrate and vertebrate species.

  Journal article

  Oppermann UC. et al, (1998), Chem Biol Interact, 114, 211 - 224

• Role of type-1 11beta-hydroxysteroid dehydrogenase in detoxification processes.

  Journal article

  Maser E. and Oppermann UC., (1997), Eur J Biochem, 249, 365 - 369

• Function, gene organization and protein structures of 11beta-hydroxysteroid dehydrogenase isoforms.

  Journal article

  Oppermann UC. et al, (1997), Eur J Biochem, 249, 355 - 360

• Active site directed mutagenesis of 3 beta/17 beta-hydroxysteroid dehydrogenase establishes differential effects on short-chain dehydrogenase/reductase reactions.

  Journal article

  Oppermann UC. et al, (1997), Biochemistry, 36, 34 - 40

• The 11β-hydroxysteroid dehydrogenase system, a determinant of glucocorticoid and mineralocorticoid action

  Journal article

  Oppermann UCT. et al, (1997), European Journal of Biochemistry, 249, 355 - 360

• Structure-function relationships of SDR hydroxysteroid dehydrogenases.

  Journal article

  Oppermann UC. et al, (1997), Adv Exp Med Biol, 414, 403 - 415

• Characterization of a 3 alpha-hydroxysteroid dehydrogenase/carbonyl reductase from the gram-negative bacterium Comamonas testosteroni.

  Journal article

  Oppermann UC. and Maser E., (1996), Eur J Biochem, 241, 744 - 749

• Leukotriene A4 hydrolase: protection from mechanism-based inactivation by mutation of tyrosine-378.

  Journal article

  Mueller MJ. et al, (1996), Proc Natl Acad Sci U S A, 93, 5931 - 5935

• Antibiotic resistance and enhanced insecticide catabolism as consequences of steroid induction in the gram-negative bacterium Comamonas testosteroni.

  Journal article

  Oppermann UC. et al, (1996), J Steroid Biochem Mol Biol, 58, 217 - 223

• Crystallization and crystal packing of recombinant 3 (or 17) beta-hydroxysteroid dehydrogenase from Comamonas testosteroni ATTC 11996.

  Journal article

  Benach J. et al, (1996), Eur J Biochem, 236, 144 - 148

• Cloning and primary structure of murine 11 beta-hydroxysteroid dehydrogenase/microsomal carbonyl reductase.

  Journal article

  Oppermann UC. et al, (1995), Eur J Biochem, 227, 202 - 208

• Molecular cloning and sequencing of mouse hepatic 11 beta-hydroxysteroid dehydrogenase/carbonyl reductase. A member of the short chain dehydrogenase superfamily.

  Journal article

  Maser E. and Oppermann UC., (1995), Adv Exp Med Biol, 372, 211 - 221

• Carbonyl reduction by 3 alpha-HSD from Comamonas testosteroni--new properties and its relationship to the SCAD family.

  Journal article

  Oppermann CT. et al, (1993), Adv Exp Med Biol, 328, 379 - 390

• Homologies between enzymes involved in steroid and xenobiotic carbonyl reduction in vertebrates, invertebrates and procaryonts.

  Journal article

  Oppermann UC. et al, (1992), J Steroid Biochem Mol Biol, 43, 665 - 675

• Functional and immunological relationships between metyrapone reductase from mouse liver microsomes and 3 alpha-hydroxysteroid dehydrogenase from Pseudomonas testosteroni.

  Journal article

  Maser E. et al, (1992), FEBS Lett, 297, 196 - 200

• Heterogeneity of carbonyl reduction in subcellular fractions and different organs in rodents

  Journal article

  Oppermann UCT. et al, (1991), Biochemical Pharmacology, 42

• Heterogeneity of carbonyl reduction in subcellular fractions and different organs in rodents.

  Journal article

  Oppermann UC. et al, (1991), Biochem Pharmacol, 42 Suppl, S189 - S195

• The influence of cytochrome P-450 inducers on carbonyl reduction in mouse liver.

  Journal article

  Maser E. et al, (1991), Arch Toxicol Suppl, 14, 188 - 192

• IMMUNOLOGICAL HOMOLOGIES BETWEEN CARBONYL REDUCING ENZYMES FROM PROKARYONTS AND MAMMALIAN LIVER-MICROSOMES

  Journal article

  MASER E. et al, (1990), EUROPEAN JOURNAL OF PHARMACOLOGY, 183, 1366 - 1366

Key Publications

• The roles of Jumonji-type oxygenases in human disease.

  Journal article

  Johansson C. et al, (2014), Epigenomics, 6, 89 - 120
• Why is epigenetics important in understanding the pathogenesis of inflammatory musculoskeletal diseases?

  Journal article

  Oppermann U., (2013), Arthritis Res Ther, 15
• A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.

  Journal article

  Kruidenier L. et al, (2012), Nature, 488, 404 - 408
• Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.

  Journal article

  Evans DM. et al, (2011), Nat Genet, 43, 761 - 767
• Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming.

  Journal article

  Kochan G. et al, (2011), Proc Natl Acad Sci U S A, 108, 7745 - 7750

Recent Publications

• The first international workshop on the epigenetics of osteoarthritis.

  Journal article

  Meulenbelt IM. et al, (2017), Connect Tissue Res, 58, 37 - 48
• Sclerostin expression in bone tumours and tumour-like lesions.

  Journal article

  Inagaki Y. et al, (2016), Histopathology, 69, 470 - 478
• A germline mutation of CDKN2A and a novel RPLP1-C19MC fusion detected in a rare melanotic neuroectodermal tumor of infancy: a case report.

  Journal article

  Barnes DJ. et al, (2016), BMC Cancer, 16
• Advances and challenges in understanding histone demethylase biology.

  Journal article

  Nowak RP. et al, (2016), Curr Opin Chem Biol, 33, 151 - 159
• H3K27me3 demethylases regulate in vitro chondrogenesis and chondrocyte activity in osteoarthritis.

  Journal article

  Yapp C. et al, (2016), Arthritis Res Ther, 18