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Sean Giblin

DPhil Student

The aim of my project is to investigate the cell-type specific biosynthesis, and post-transcriptional regulation, of the pro-inflammatory extracellular matrix molecule tenascin-C.

My work focuses on dissecting how alternative splicing patterns change during acute and chronic models of inflammation; and investigating the role played by tenascin-C during the formation of the immunological synapse. These objectives will be achieved using a combination of qPCR, ELISA, Western Blot, confocal microscopy and total internal reflection fluorescence microscopy techniques.