Contact information
Research groups
Sara Danielli
Postdoctoral Researcher
I am a postdoc researcher in Jelena Bezbradica Mirkovic lab where I study the way in which the innate immune system can sense environmental signals and initiate the appropriate inflammatory response.
I have previously worked in the lab of Prof. Katja Simon at the Weatherall Institute of Molecular Medicine where I looked at the role of autophagy in neutrophil differentiation and in Prof Julian Knight and Dr Benjamin Fairfax at the Wellcome Trust Centre of Human Genetics, where I worked on cancer immunology.
During my DPhil in Jelena Bezbradica Mirkovic lab, I investigated the role of CALHM6 a tetraspanin membrane protein in the response to bacterial infection, and in particular in the immunological synapse.
Key publications
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Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation.
Journal article
Riffelmacher T. et al, (2017), Immunity, 47, 466 - 480.e5
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Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele.
Journal article
Al-Mossawi H. et al, (2019), Nat Commun, 10
Recent publications
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The ion channel CALHM6 controls bacterial infection-induced cellular cross-talk at the immunological synapse.
Journal article
Danielli S. et al, (2023), EMBO J
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Natural Killer cells demonstrate distinct eQTL and transcriptome-wide disease associations, highlighting their role in autoimmunity.
Journal article
Gilchrist JJ. et al, (2022), Nat Commun, 13
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How Pyroptosis Contributes to Inflammation and Fibroblast-Macrophage Cross-Talk in Rheumatoid Arthritis.
Journal article
Demarco B. et al, (2022), Cells, 11
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TBK1 and IKKε act like an OFF switch to limit NLRP3 inflammasome pathway activation.
Journal article
Fischer FA. et al, (2021), Proc Natl Acad Sci U S A, 118
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Characterising the cfDNA Methylome in Patients with Metastatic Melanoma Treated with Immune Checkpoint Blockade
Conference paper
Cooper R. et al, (2021), JOURNAL OF PATHOLOGY, 255, S40 - S40