Sara Danielli

Postdoctoral Researcher

I am a postdoc researcher in Jelena Bezbradica Mirkovic lab where I study the way in which the innate immune system can sense environmental signals and initiate the appropriate inflammatory response.

I have previously worked in the lab of Prof. Katja Simon at the Weatherall Institute of Molecular Medicine where I looked at the role of autophagy in neutrophil differentiation and in Prof Julian Knight and Dr Benjamin Fairfax at the Wellcome Trust Centre of Human Genetics, where I worked on cancer immunology.

During my DPhil in Jelena Bezbradica Mirkovic lab, I investigated the role of CALHM6 a tetraspanin membrane protein in the response to bacterial infection, and in particular in the immunological synapse.

Key publications

Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation.
Journal article

Riffelmacher T. et al, (2017), Immunity, 47, 466 - 480.e5
Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele.
Journal article

Al-Mossawi H. et al, (2019), Nat Commun, 10

Recent publications

How Pyroptosis Contributes to Inflammation and Fibroblast-Macrophage Cross-Talk in Rheumatoid Arthritis.
Journal article

Demarco B. et al, (2022), Cells, 11
TBK1 and IKKε act like an OFF switch to limit NLRP3 inflammasome pathway activation.
Journal article

Fischer FA. et al, (2021), Proc Natl Acad Sci U S A, 118
Characterising the cfDNA Methylome in Patients with Metastatic Melanoma Treated with Immune Checkpoint Blockade
Conference paper

Cooper R. et al, (2021), JOURNAL OF PATHOLOGY, 255, S40 - S40
Natural Killer cells demonstrate distinct eQTL and transcriptome-wide disease associations, highlighting their role in autoimmunity
Journal article

Gilchrist JJ. et al, (2021)
Defining subset-wise myeloid responses to immune checkpoint blockade in melanoma
Conference paper

Cooper R. et al, (2021), ANNALS OF ONCOLOGY, 32, S1211 - S1211

More publications