Raphael Sanches Peres
EMBO Research Fellow
I concluded my PhD in Brazil at University of São Paulo studying the immunological mechanisms associated with methotrexate resistance in patients with rheumatoid arthritis. I joined to the Fiona Powie’s group at the Kennedy Institute of Rheumatology in 2017 when I got an EMBO Long-Term Fellowship.
I have interest in translational research that investigates the contribution of regulatory T (Treg) cells in the maintenance of the immunological homeostasis and the events linked to Tregs biology that have impact in the development, establishment and resolution of chronic inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease. Furthermore, my interest is to develop therapeutic strategies for inflammatory diseases focused in the manipulation of Tregs cells function and also to determine how this cell population could influence in the efficacy of therapeutic agents available in the clinic, such as methotrexate and TNF inhibitors.
TGF-β signalling defect is linked to low CD39 expression on regulatory T cells and methotrexate resistance in rheumatoid arthritis.
Peres RS. et al, (2018), J Autoimmun
Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis.
Peres RS. et al, (2017), Arthritis Res Ther, 19
Neutrophil Recruitment and Articular Hyperalgesia in Antigen-Induced Arthritis are Modulated by the Cholinergic Anti-Inflammatory Pathway.
Kanashiro A. et al, (2016), Basic Clin Pharmacol Toxicol, 119, 453 - 457
Pharmacological opportunities to control inflammatory diseases through inhibition of the leukocyte recruitment.
Peres RS. et al, (2016), Pharmacol Res, 112, 37 - 48
Acute Strongyloides venezuelensis infection did not prevent EAE development: implications for hygiene hypothesis
Chiuso-Minicucci F. et al, (2016), TROPICAL BIOMEDICINE, 33, 526 - 534