Matthias Friedrich
Postdoctoral Researcher (Oxford-Janssen)
I am passionate about translating research findings into clinical benefit for patients with immune-mediated inflammatory diseases (IMIDs). Within the Oxford-Janssen Cartography project (lead: Prof. Uhlig) and as part of Chris Buckley's research group, I focus on dissecting pathogenic molecular and cellular networks in rheumatoid arthritis and psoriatic arthritis. Through applying cross-disease multi-omic patient cohort profiling, molecular and cellular biology, and bioinformatic analyses, this will allow us to identify potential therapeutic targets to develop improved medicines.
Recent publications
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BMP pathway antagonism by Grem1 regulates epithelial cell fate in intestinal regeneration
Journal article
LEEDHAM S. et al, (2021), Gastroenterology
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Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease.
Journal article
Friedrich M. et al, (2019), Immunity, 50, 992 - 1006
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Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.
Journal article
West NR. et al, (2017), Nat Med, 23, 579 - 589
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Solid Organ Transplantation in Patients with Inflammatory Bowel Diseases (IBD): Analysis of Transplantation Outcome and IBD Activity in a Large Single Center Cohort
Journal article
Schnitzler F. et al, (2015), PLOS ONE, 10, e0135807 - e0135807
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Lipocalin-2 Is a Disease Activity Marker in Inflammatory Bowel Disease Regulated by IL-17A, IL-22, and TNF-α and Modulated by IL23R Genotype Status
Journal article
Stallhofer J. et al, (2015), Inflammatory Bowel Diseases, 1 - 1