Research groups
Matthias Friedrich
Postdoctoral Researcher (Oxford-Janssen)
I am passionate about translating research findings into clinical benefit for patients with immune-mediated inflammatory diseases (IMIDs). Within the Oxford-Janssen Cartography project (lead: Prof. Uhlig) and as part of Chris Buckley's research group, I focus on dissecting pathogenic molecular and cellular networks in rheumatoid arthritis and psoriatic arthritis. Through applying cross-disease multi-omic patient cohort profiling, molecular and cellular biology, and bioinformatic analyses, this will allow us to identify potential therapeutic targets to develop improved medicines.
Recent publications
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Systemic and T cell-associated responses to SARS-CoV-2 immunisation in gut inflammation (STAR SIGN study): effects of biologics on vaccination efficacy of the third dose of mRNA vaccines against SARS-CoV-2.
Journal article
Woelfel S. et al, (2022), Aliment Pharmacol Ther
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Hermansky-Pudlak syndrome type 1 causes impaired anti-microbial immunity and inflammation due to dysregulated immunometabolism.
Journal article
Cavounidis A. et al, (2022), Mucosal Immunol
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BMP pathway antagonism by Grem1 regulates epithelial cell fate in intestinal regeneration
Journal article
LEEDHAM S. et al, (2021), Gastroenterology
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IL-1-driven stromal-neutrophil interaction in deep ulcers defines a pathotype of therapy non-responsive inflammatory bowel disease
Journal article
Friedrich M. et al, (2021)
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Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases
Preprint
Korsunsky I. et al, (2021)