Contact information
Research groups
Mathilde Pohin
Postdoctoral Research Scientist
Leukocytes -stromal interaction in IBD
After completing a PhD in cellular and molecular immunology in the University of Poitiers (France), I joined the Kennedy Institute of Rheumatology in November 2017.
My research aims to understand the function of stromal cells in IBD and how these cells interact with immune cells to sustain chronic inflammation. I am dissecting the cellular and molecular landscape of inflamed tissue from IBD patients with gene expression profiling, quantitative in situ analyses, multiplexed image fluorescence and functional ex vivo assays. I am also using in vivo mouse models of IBD to interrogate key pathways involved in IBD pathophysiology. and identify new therapeutic targets.
Recent publications
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MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T-cell responses.
Journal article
Heuberger CE. et al, (2024), Mucosal Immunol, 17, 416 - 430
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Adipocyte autophagy limits gut inflammation by controlling oxylipin and IL-10.
Journal article
Richter FC. et al, (2023), EMBO J
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MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T cell responses
Preprint
Heuberger CE. et al, (2023)
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Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases.
Journal article
Korsunsky I. et al, (2022), Med (N Y), 3, 481 - 518.e14
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IL-1-driven stromal-neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies.
Journal article
Friedrich M. et al, (2021), Nat Med, 27, 1970 - 1981