Oxford Celgene Fellow
I am a postdoctoral fellow working with Mark Coles at the Kennedy Institute and Eamonn Gaffney at the Mathematical Institute. I work in collaboration with Celgene.
My research interests lie in cancer immunology, particularly in T-cell therapeutics. I am interested in using quantitative (mathematical and computational) techniques to constrain our knowledge of biological mechanisms and processes, and quantify how these may differ between mice and humans.
For example, lymphatic drainage times are five-fold faster in mice than humans. Could this therefore lead to a difference in how mouse models and patients may respond to a therapeutic given intradermally, if the therapeutic has a known half-life in the body?
To see more, please visit my website on the mathematics website.
Quantifying the limits of CAR T-cell delivery in mice and men
BROWN L. et al, (2021), Journal of the Royal Society Interface
Brown LV. et al, (2018), Clin Exp Immunol, 193, 284 - 292
Brown LV. et al, (2018), J R Soc Interface, 15