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Jonathan Hamp

Postdoctoral Research Associate

Immunologist focusing on T cell interactions during inflammation

Summary

Prior to starting my position at the Kennedy Institute, I attained my PhD at the University of York under the supervision of Professors Paul Kaye and Jon Timmis, I was also co-supervised by Professor Simon Croft of the London School of Hygiene & Tropical Medicine. Visceral leishmaniasis is a neglected tropical disease that causes as estimated 20,000-30,000 deaths every year. Therapeutic options for this disease are limited and drug resistance is increasing. My work focused on investigating the sub-tissue level distribution of drug during parasitic infection, with the aim of elucidating information that could help inform drug discovery and benefit therapeutic regime design. For this I combined traditional immunological and pharmacological approaches with mathematical modelling.

Currentlywithin the group of Dr. Luke Jostins, I am focusing on the interaction of T cells and antigen presenting cells, specifically looking at the role of various signalling molecules and the downstream effects these induce. Using T cells isolated from healthy volunteers and IBD patients we hope to combine phenotypic and genotypic approaches to examine the relevance of these signalling molecules with regards to IBD-risk, and investigate the possibility of these molecules stratifying patient sub-populations.