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Enas Abu Shah


Postdoctoral Research Assistant

Quantitative analysis of human regulatory networks.

I obtained my PhD in Nanotechnology from the Technion Institute of Technology (Israel). During my PhD in Dr. Kinneret Keren's lab, I established an in-vitro cell-like system to study the biophysical aspect of cytoskeletal organisation and in particular the process of symmetry breaking in acto-myosin networks [1].

I joined the lab of Prof. Michael Dustin as a joint postdoctoral fellow with Omer Dushek to study immunoregulatory networks using mathematical models. I have established a three-dimensional collagen gel incorporating human effector T-cells and antigen presenting cells (APCs) to mimic 3D tissue architecture. Using time-lapse microscopy I follow the interactions between the T-cells and the APCs in the presence and absence of regulatory T-cells. By analysing the kinetic parameters of the contacts formed between the T-cells and APCs and fitting them to a variety of mathematical models we anticipate to reveal the inhibition mechanism employed by regulatory T-cells as a function of antigen dose and potency. These models will include communication via direct cell-cell contacts, soluble factors and extracellular vesicles.

My work is supported in part by the Human Frontiers Science Program [2,3].

References

  1. Abu-Shah, E. and K. Keren, Symmetry breaking in reconstituted actin cortices, ed. M. Balasubramanian. Vol. 3. 2014. 
  2. HFSP AWARDS 2015, Research Grants 
  3. International research project gets high level of funding

HFSP AWARDS 2015

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Recent Publications

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