Postdoctoral Research Associate
- Oxford-UCB Research Fellow
Quantitative analysis of human regulatory networks.
I obtained my PhD in Nanotechnology from the Technion Institute of Technology (Israel). During my PhD in Dr. Kinneret Keren's lab, I established an in-vitro cell-like system to study the biophysical aspect of cytoskeletal organisation and in particular the process of symmetry breaking in acto-myosin networks .
I joined the lab of Prof. Michael Dustin as a joint postdoctoral fellow with Omer Dushek to study immunoregulatory networks using mathematical models. I have established a three-dimensional collagen gel incorporating human effector T-cells and antigen presenting cells (APCs) to mimic 3D tissue architecture. Using time-lapse microscopy I follow the interactions between the T-cells and the APCs in the presence and absence of regulatory T-cells. By analysing the kinetic parameters of the contacts formed between the T-cells and APCs and fitting them to a variety of mathematical models we anticipate to reveal the inhibition mechanism employed by regulatory T-cells as a function of antigen dose and potency. These models will include communication via direct cell-cell contacts, soluble factors and extracellular vesicles.
My work was supported in part by the Human Frontiers Science Program [2,3].
- Abu-Shah, E. and K. Keren, Symmetry breaking in reconstituted actin cortices, ed. M. Balasubramanian. Vol. 3. 2014.
- HFSP AWARDS 2015, Research Grants
- International research project gets high level of funding
HFSP AWARDS 2015
Abu-Shah E. et al, (2019), Elife, 8
Artificial antigen presenting cells for detection and desensitisation of auto-reactive T-cells associated with Type 1 Diabetes
ABU SHAH E. et al, (2019), Biomaterials
T cell regulation in pancreatic ductal adenocarcinoma
ABU SHAH E. et al, (2019)
Mayya V. et al, (2019), J Immunol
Malik-Garbi M. et al, (2019), NATURE PHYSICS, 15, 509 - +