Elizabeth Mann
Postdoc and Powrie cancer team lead
Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths world-wide, for which a variety of genetic and environmental risk factors are known to exist. One molecule that is known to promote CRC in mouse models of disease is the Th17-family cytokine IL-23. In human CRC, levels of IL-23 are similarly elevated but it's function in disease progression remains poorly understood.
My research aims to uncover the mechanistic role(s) of IL-23 and Th17 cells in human CRC tumours. Insights from these studies will hopefully inform the development of novel diagnostic assays and therapeutics for CRC, particularly focusing on subsets of patients that have poor prognosis.
Key publications
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SARS-CoV-2 has a sweet tooth.
Journal article
Cavounidis A. and Mann EH., (2020), Nat Rev Immunol
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The Interleukin 22 Pathway Interacts with Mutant KRAS to Promote Poor Prognosis in Colon Cancer.
Journal article
McCuaig S. et al, (2020), Clin Cancer Res, 26, 4313 - 4325
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High-Dose IL-2 Skews a Glucocorticoid-Driven IL-17+IL-10+ Memory CD4+ T Cell Response towards a Single IL-10–Producing Phenotype
Journal article
Mann EH. et al, (2019), The Journal of Immunology, 202, 684 - 693
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Immunoregulatory mechanisms of vitamin D relevant to respiratory health and asthma
Journal article
Mann EH. et al, (2014), Annals of the New York Academy of Sciences, 1317, 57 - 69
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Vitamin D Counteracts an IL-23–Dependent IL-17A+IFN-γ+Response Driven by Urban Particulate Matter
Journal article
Mann EH. et al, (2017), American Journal of Respiratory Cell and Molecular Biology, 57, 355 - 366
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Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence
Journal article
Sapey E. et al, (2014), Blood, 123, 239 - 248