Tenascin-C is an extracellular matrix protein which is overexpressed during inflammatory diseases such as malignant cancers. In metastatic breast cancer in particular, the expression of high levels of tenascin-C is associated with a dramatic decrease of the patient’s survival.
My project consists in using cell biology technics and tumour models to decipher how tenascin-C impacts the differentiation, the prognosis value and the polarization of the adaptive immune response within the microenvironment of primary and metastatic tumours.
Deligne C. et al, (2015), Osteoarthritis Cartilage, 23, 1843 - 1852
Deligne C. et al, (2015), Leukemia, 29, 947 - 957
Deligne C. and Teillaud J-L., (2013), Med Sci (Paris), 29, 57 - 63