Brian Marsden

D.Phil.

Principal Investigator, Research Informatics Group

After completing a D.Phil. within the Iain Campbell lab at the University of Oxford, Brian was awarded a Wellcome Trust Prize Fellowship which he spent at the Abagyan lab at the Scripps Research Institute, La Jolla, USA, devising novel methods for proteins structure superimposition and also implementing high performance compute and storage clusters. He then worked as part of the Computational Chemistry group at BioFocus PLC before settling down at the SGC in Oxford where he continues to be responsible for all aspects of Informatics, IT and structural bioinformatics. He has a particular interest in the development of novel data capture and visualisation methods for structural and chemical biology data.

Since 2013, Brian has split his time with the Kennedy Institute where he and his team are responsible for the provision of IT capabilities as well as effective data management platforms to support the broad range of science within the Institute.

Key publications

OOMMPPAA: a tool to aid directed synthesis by the combined analysis of activity and structural data.
Journal article

Bradley AR. et al, (2014), J Chem Inf Model, 54, 2636 - 2646
ChromoHub: a data hub for navigators of chromatin-mediated signalling.
Journal article

Liu L. et al, (2012), Bioinformatics, 28, 2205 - 2206
A new method for publishing three-dimensional content.
Journal article

Raush E. et al, (2009), PLoS One, 4
SGC--structural biology and human health: a new approach to publishing structural biology results.
Journal article

Lee WH. et al, (2009), PLoS One, 4
Structural genomics of histone tail recognition.
Journal article

Wang M. et al, (2010), Bioinformatics, 26, 2629 - 2630

Recent publications

Donated chemical probes for open science.
Journal article

Müller S. et al, (2018), Elife, 7
Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers.
Journal article

Zuliani-Alvarez L. et al, (2017), Nat Commun, 8
The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery.
Journal article

Bradley AR. et al, (2017), Essays Biochem, 61, 495 - 503
Suramin Inhibits Osteoarthritic Cartilage Degradation by Increasing Extracellular Levels of Chondroprotective Tissue Inhibitor of Metalloproteinases 3.
Journal article

Chanalaris A. et al, (2017), Mol Pharmacol, 92, 459 - 468
Partial-occupancy binders identified by the Pan-Dataset Density Analysis method offer new chemical opportunities and reveal cryptic binding sites.
Conference paper

Pearce NM. et al, (2017), Struct Dyn, 4

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