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Anna Piccinini

Honorary Departmental Senior Research Associate

When infection or injury occurs, the innate immune response ensures that damaged tissues are repaired and homeostasis is re-established. De-regulation of this response can lead to autoimmunity and systemic inflammation. However, it remains unclear how the mechanisms that keep the immune response in check fail.

The extracellular matrix (ECM), a dynamic 3D network of secreted molecules, creates a microenvironment that interacts with cells, regulating and instructing their behaviour. My previous research has investigated how ECM molecules, induced exclusively upon tissue injury, regulate inflammatory signalling pathways.

My recent work has focused on the role of the ECM in the immune response to infection and has been recognized by the Young Investigator Award from the British Society for Matrix Biology.

I recently relocated to the University of Nottingham (School of Pharmacy, Division of Molecular and Cellular Science) where I have commenced a 3 year Anne McLaren Fellowship. I aim to dissect how the three-dimensional cell microenvironment influences the posttranscriptional regulation of the innate immune response.