Gene delivery to the corneal endothelium.
George AJ., Arancibia-Cárcamo CV., Awad HM., Comer RM., Fehevari Z., King WJ., Kadifachi M., Hudde T., Kerouedan-Lebossé C., Mirza F., Barbaros Oral H., Rayner SA., Tan PH., Tay E., Larkin DF.
Gene transfer to the corneal endothelium has potential for modulating rejection of corneal grafts. It can also serve as a convenient and useful model for gene therapy of other organs. In this article we review the work carried out in our laboratory using both viral and nonviral vectors to obtain gene expression in the cornea.