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The interaction of antigen with immunologically competent cells may lead either to the induction of an immune response or to a state of antigen specific unresponsiveness complete orpartial, which is often called immunological 'tolerance'. This is believed to be a major mechanism of discrimination between self and non-self(1-3). In this review Marc Feldmann and his colleagues discuss new insights into T-cell tolerance in vivo and in vitro, and discuss their significance for our understanding of mechanisms of immune activation and regulation.

Original publication

DOI

10.1016/0167-5699(85)90049-0

Type

Journal article

Journal

Immunol Today

Publication Date

02/1985

Volume

6

Pages

58 - 62