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A small library of ferrocene-based 1,2,3-triazole-containing hydroxamic acids has been synthesised employing click chemistry: 7-(4-ferrocenyl-1H-1,2,3- triazol-1-yl)-N-hydroxyheptanamide, 4b, containing the 1,2,3-triazole moiety adjacent to the ferrocene group, displayed excellent HDAC inhibition and activity in cells, inhibiting the deacetylation of tubulin as well as inducing cell cycle arrest. © The Royal Society of Chemistry.

Original publication

DOI

10.1039/c1md00203a

Type

Journal article

Journal

MedChemComm

Publication Date

01/01/2012

Volume

3

Pages

61 - 64