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<jats:title>Abstract</jats:title> <jats:p>The Coronavirus infectious disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a world health concern and can cause severe disease and high mortality in susceptible groups. While vaccines offer a chance to treat disease, prophylactic and anti-viral treatments are still of vital importance, especially in context of the mutative ability of this group of viruses. Therefore, it is essential to elucidate the molecular mechanisms of viral entry, innate sensing, and immune evasion of SARS-CoV-2 which control the triggers of the subsequent excessive inflammatory response. Viral evasion strategies directly target anti-viral immunity, counteracting host restriction factors and hijacking signalling pathways to interfere with interferon production. In part one of this review we examine SARS-CoV-2 viral entry and the described immune evasion mechanisms and provide a perspective on how the failure in initial viral sensing by infected cells can lead to immune dysregulation causing fatal COVID-19, discussed in part two.</jats:p>

Original publication

DOI

10.1093/oxfimm/iqaa004

Type

Journal article

Journal

Oxford Open Immunology

Publisher

Oxford University Press (OUP)

Publication Date

08/12/2020