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Mosquitoes are vectors of parasitic and viral diseases of immense importance for public health. The acquisition of the genome sequence of the yellow fever and Dengue vector, Aedes aegypti (Aa), has enabled a comparative phylogenomic analysis of the insect immune repertoire: in Aa, the malaria vector Anopheles gambiae (Ag), and the fruit fly Drosophila melanogaster (Dm). Analysis of immune signaling pathways and response modules reveals both conservative and rapidly evolving features associated with different functional gene categories and particular aspects of immune reactions. These dynamics reflect in part continuous readjustment between accommodation and rejection of pathogens and suggest how innate immunity may have evolved.

Original publication

DOI

10.1126/science.1139862

Type

Journal article

Journal

Science

Publication Date

22/06/2007

Volume

316

Pages

1738 - 1743

Keywords

Aedes, Animals, Anopheles, Antimicrobial Cationic Peptides, Carrier Proteins, Drosophila melanogaster, Evolution, Molecular, Genes, Insect, Immunity, Innate, Insect Proteins, Insect Vectors, Malaria, Melanins, Multigene Family, Signal Transduction, Species Specificity