Inhibition of interleukin-17-induced effects in osteoarthritis - An in vitro study
Mimpen JY., Carr AJ., Dakin SG., Snelling SJ.
Interleukin-17A (IL-17) is a pro-inflammator¬y cytokine, which has been reported to be increased in the joint of patients with OA. This study aimed to identify whether IL-17 or its receptors are expressed in the joints of OA patients and establish the effect of IL-17 in vitro on primary human chondrocytes and synovial fibroblasts from the joints of OA patients. We further studied whether any anti-inflammatory agents in current clinical use were able to reduce the effects of IL-17. We hypothesize that IL-17 stimulates the production of matrix degrading and inflammatory proteins by acting on IL-17 receptors on chondrocytes and synovial fibroblasts, which can be blocked by clinically used anti-inflammatory therapeutics.