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Oxford to collaborate with Janssen to map the cellular landscape of immune mediated disorders

Research

22 February 2021

The University of Oxford has entered into a strategic collaboration with Janssen Biotech, Inc., one of the Janssen Pharmaceutical Companies of Johnson & Johnson.

Vascular loss shown to be the primary hallmark of aging

Research

4 February 2021

New Research from the Kusumbe group at the Kennedy Institute of Rheumatology identifies vascular attrition, marked by pericyte to fibroblast differentiation, as a primary hallmark of aging and highlights organ-specific vascular changes with age.

Immunology preprint reviews launched in Nature Reviews Immunology

Research

15 January 2021

The Oxford-Mount Sinai (OxMS) Preprint Journal Club has partnered with Nature Reviews Immunology to launch a monthly Preprint Watch column.

Drug may boost vaccine responses in older adults

General Research

18 December 2020

A preliminary study shows that a drug which helps immune cells self-clean may improve vaccine protection in older adults

Living reviews launched by Oxford and Cardiff in the wake of COVID-19 research

Research

18 December 2020

In a combined effort to help COVID-19 researchers the University of Oxford and Cardiff University have launched a series of “living reviews” in Oxford University Press’s new open access journal “Oxford Open Immunology”.

3D imaging reveals the role of blood vessels in hormone production

Research

11 December 2020

New research from the Kusumbe Group at the Kennedy Institute has shown a direct correlation between age-related decline in capillary and artery numbers and hormone production in the endocrine system.

Wellcome funding awarded to Oxford team to support research into heart muscle regeneration

Awards Research

24 November 2020

An Oxford team from the Centre for Medicines Development, Department of Physiology Anatomy and Genetics and Radcliffe Department of Medicine led by Professor Jagdeep Nanchahal at the Kennedy Institute has been awarded a Wellcome Innovator Award to develop a first in class therapeutic aimed at regenerating heart muscle after heart attack.

An unexpected repair function for neutrophils

Research

30 October 2020

In a collaboration with scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC), Kennedy researchers have contributed to the discovery that neutrophils have many more functions in the body than previously thought. This finding suggests that neutrophil tissue-specific plasticity could be exploited in designing new treatments for neutrophil driven diseases, including cancer.

Understanding the physics of the immune response necessitates new technology

Research

23 October 2020

Professor Marco Fritzsche has joined the Kennedy Institute as the Principal Investigator of the Biophysical Immunology Laboratory (BPI), as part of a joint appointment with the Rosalind Franklin Institute. His lab is leading the development of a lattice light sheet microscope that will significantly advance the study of live cells.

CD2 corolla calls T cells to arms

Research

20 October 2020

A team from the University of Oxford has visualised how key cells of the immune system lock onto cancerous or infected cells to destroy them. The work was led by the Mike Dustin’s group at the Kennedy Institute of Rheumatology and experts in colorectal and ovarian cancers from across Oxford and computational biologists at the University of Birmingham.

New target identified to treat anaemia in inflammatory disease

Research

11 June 2020

Understanding of inflammatory bowel disease moves a step closer

Research

23 May 2020

Published in Science Immunology, researchers at the Kennedy Institute have identified the role of IRF5 in controlling intestinal inflammation.

Researchers identify markers in joint fluid that could be the key to cartilage repair

General Research

9 March 2020

Molecular changes in the joint fluid during surgical joint distraction reveal markers that may drive cartilage repair in osteoarthritis.

Cancer progression may be controlled by targeting tumor-specific extracellular matrix

Research

15 January 2020

Researchers have uncovered how tumors exploit tenascin-C to deflect the body’s natural defence against them.

Researchers identify link in the treatment of inflammatory bowel disease (IBD)

Research

6 December 2019

A new study published in the Journal of Experimental Medicine reveals how IL-10 and PGE2 work together to prevent inflammatory tissue damage and maintain a healthy gut balance

Dissecting TNF signalling in inflammatory disease

Research

28 October 2019

New research from Dr Richard Williams’ group at the Kennedy Institute suggests a route for the development of more selective – and effective – therapies for immune-mediated inflammatory disease.

Study links blood vessels to therapy resistance in cancer metastasis to bone

Research

15 July 2019

A new study from the Kennedy Institute of Rheumatology reveals a role for blood vessels in promoting therapy resistance of cancer metastasis in bone.

Vaccine developed to treat osteoarthritic pain

Publication Research oacentre

12 March 2019

Researchers have developed a vaccine that blocks the effects of the main cause of pain in osteoarthritis (OA) - nerve growth factor (NGF) - in mice.

New drug class could offer a targeted safer treatment alternative for patients with rheumatoid arthritis

Publication Research

15 February 2019

A new treatment targeting tenascin-C could reduce the progression and severity of rheumatoid arthritis (RA) at the very early stages of disease.

Study suggests immune system plays key role in survival after pancreatic cancer surgery

Publication Research

12 February 2019

Researchers in Oxford have found that an individual’s immune system – and in particular the presence of T-cells amongst tumour cells – may play an important role in survival after surgery to remove pancreatic cancer.