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Autophagy-dependent generation of free fatty acids is critical for normal neutrophil differentiation

Autophagy-dependent generation of free fatty acids is critical for normal neutrophil differentiation

Publication Research

Recent research from the Simon Group has discovered an unexpected novel role that autophagy plays during the generation of neutrophils.

New potential treatment target for patients with inflammatory bowel disease

New potential treatment target for patients with inflammatory bowel disease

Publication Research

A new study published today in Nature Medicine could change the lives of millions of people living with inflammatory bowel diseases (IBD) who don’t respond to the current standard of care.

Time to be positive about negative data?

Time to be positive about negative data?

Publication

Professor Tonia Vincent writes in Osteoarthritis and Cartilage about the importance of making negative data more accessible in osteoarthritis research.

Getting it 'just right' in the immune system

Getting it 'just right' in the immune system

Publication Research

Two Kennedy Institute scientists have proposed a solution to a puzzle of the human immune system: how our immune system scales its response in proportion to any threat to our health to make it 'just right'. Their ideas, published in the journal Trends in Immunology, could support a range of medical research.

Blood test that could predict arthritis

Blood test that could predict arthritis

Publication Research

Scientists have found a marker that can indicate your likelihood of suffering from rheumatoid arthritis (RA) even sixteen years before the condition takes effect.

New hope for patients with Inflammatory Bowel Disease

New hope for patients with Inflammatory Bowel Disease

Publication

A new study led by researchers at the Kennedy Institute and published today in Immunity sheds light on the drivers behind Inflammatory bowel disease (IBD) and suggests potential new targets for treatment of the condition.

New hope for patients with cancer-induced bone diseases

New hope for patients with cancer-induced bone diseases

Publication Research

Researchers at the Kennedy Institute, part of NDORMS have repurposed the approved drug miglustat to successfully slow the progression of multiple myeloma.

Blocking obesity-associated protein stops dangerous fat formation

Blocking obesity-associated protein stops dangerous fat formation

Publication

By changing mouse genes to block a protein associated with obesity, researchers at the Kennedy Institute of Rheumatology, NDORMS have prevented fat from forming around the animals' internal organs, even when the animals eat an unhealthy diet. The study in Nature Medicine found that these genetically engineered mice also retained their sensitivity to insulin (normally blunted by obesity), despite gaining weight.

New role for Wiskott-Aldrich Syndrome protein

New role for Wiskott-Aldrich Syndrome protein

Publication Research

New research published today in eLife demonstrates a new function for Wiskott-Aldrich Syndrome (WAS) protein in the activation of T cells, which play a central role in our immune system.