Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence
Sapey E., Greenwood H., Walton G., Mann E., Love A., Aaronson N., Insall RH., Stockley RA., Lord JM.
<jats:title>Key Points</jats:title> <jats:p>Constitutive PI3K activity is associated with less accurate neutrophil migration in healthy aged adults. This is associated with increased primary granule release and neutrophil elastase activity and may contribute to inflammation and infection.</jats:p>