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Monocytes as cells of the innate immunity are prominently involved in the development of atherosclerotic lesions. The heterogeneity of blood monocytes has widely been acknowledged by accumulating experimental and clinical data suggesting a differential, subset-specific contribution of the corresponding subpopulations to the pathology of cardiovascular and other diseases. This document re-evaluates current nomenclature and summarises key findings on monocyte subset biology to propose a consensus statement about phenotype, separation and quantification of the individual subsets.

Original publication

DOI

10.1160/TH16-02-0091

Type

Journal article

Journal

Thromb Haemost

Publication Date

27/09/2016

Volume

116

Pages

626 - 637

Keywords

Atherosclerosis, leukocyte function / activation, monocytes, Atherosclerosis, Cardiovascular Diseases, Consensus, Humans, Monocytes, Thrombosis